Sereno: Brain unfolding, flattening, and activity movies

Sereno: Brain unfolding, flattening, and activity movies

Brain unfolding and flattening to view multiple visual areas

We have developed algorithms for stripping off the skull and then reconstructing the complete folded cortical surface of each cerebral hemisphere from structural MRI images. Once we have obtained a surface free of topological defects, it can be unfolded to better view the location of visual areas which in real life are partly hidden in deep fissures (sulci). This procedure works by gradually reducing curvature while trying to minimize areal and angular distortion. "